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| CLINICAL DEVELOPMENT PIPELINE | |
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HGS has a well balanced and deep portfolio of novel drugs directed toward diseases that represent significant unmet medical need. Three of these products are in late-stage development. BENLYSTA™ (belimumab) has successfully completed Phase 3 development in systemic lupus, and we expect the submission of marketing applications in the United States, Europe and other regions in the first half of 2010. ZALBIN™ (albinterferon alfa-2b) has successfully completed Phase 3 development in chronic hepatitis C. We have submitted a Biologics License Application to the FDA for ZALBIN in the United States, and Novartis has submitted a Marketing Authorization Application to the European Medicines Agency (EMEA) under the brand name JOULFERON® in Europe. We are developing both of these products in collaboration with world leaders in the pharmaceutical industry. In May, we submitted a Biologics License Application to the FDA for raxibacumab for the treatment of inhalational anthrax. Right behind these late-stage products is an emerging high-potential mid-stage pipeline, led by our anti-cancer products, mapatumumab, a TRAIL receptor antibody, and HGS 1029, an IAP inhibitor. We also have substantial financial rights to a number of products in the GlaxoSmithKline clinical pipeline. GSK is conducting Phase 3 clinical trials of darapladib in men and women with chronic coronary heart disease and Syncria® (albiglutide) in patients with type 2 diabetes mellitus.
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